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B.B. King named his guitar Lucille after a historic visit to the small town of Twist, Arkansas, on an evening in the 1950s.
After a woman accidentally fell and spilled heating gas on the floor, the building caught on fire; she and a man upset by the fire "brawled" while everyone tried to escape the building.
King's world-famous Gibson guitar got its name that night because "the lady who started the brawl was named Lucille." Listen to King tell the story himself in this 1968 MCA recording: