America's soaring drug prices are suddenly getting lots of attention. For that, you can thank Martin Shkreli, the much-loathed CEO of Turing Pharmaceuticals who recently raised the price of an anti-parasitic drug by 5,500 percent. Overnight, a single tablet went from $13.50 to $750, making an essential medicine unreachable for some.
Many people have wondered how Shkreli could do something like this. But to understand that story, you first have to understand how the US system of drug pricing actually works — and why it's so wildly different from other countries.
1) In the United States, drug prices are set by the market — unlike elsewhere
In other countries with single-payer systems, governments exert much more influence over the entire health care process. That allows them to negotiate directly with drugmakers. The government sets a maximum price that it will pay for a drug, and if the company doesn't agree, it simply loses out on the entire market. This puts drugmakers at a disadvantage, driving down the price of drugs.
The United States, by contrast, has long taken more of a free market approach to drugs. Pharmaceutical companies can haggle over prices with a variety of private insurers as well as selling to the government. What's more, Medicare, the government program that is the nation's largest buyer of drugs, is actually barred from negotiating drug prices. That gives Pharma much more leverage.
So drug companies here do what any other profit-maximizing company does — they try to get the highest prices possible without going so high that no one will buy them. And they do this because they can. Martin Shkreli could set the price of drugs as high as he thought the market would bear. There was no government regulator pushing back.
There are some upsides to this system — but also clear downsides, as we'll see below.
2) Drug companies consider a number of key factors in setting prices
There's no magic formula for how drug companies decide on prices, and since pricing information is considered proprietary, it's largely hashed out in private, usually in negotiations between drug companies and insurers. But experts say companies usually consider a number of factors:
- How many people will buy the drug
- How many of those will be privately insured or on Medicare or Medicaid
- The drug's benefit, according to clinical trials and real-world experience
- How many other similar drugs are already on the market
- How competitors have priced their products
- How often people will use the drug (i.e., a lifetime, or a week)
- How much it costs to develop and manufacture the product
- How long the patent on the drug will last (ensuring the company market exclusivity)
But at the end of the day, drug companies are considering profitability — they are not trying to figure out what price will benefit the most people. Back in 2012, the drugmaker Gilead sold Sovaldi, which was then the only cure for hepatitis C, at $1,000 per tablet, or $84,000 for a course of treatment. That meant that only one-tenth of the people who needed it could afford it. But Gilead was not a charity, trying to help the greatest number of people. It was trying to recoup its costs and maximize profit.
3) Americans pay more for drugs than those in other countries
Perhaps not surprisingly, drug prices are higher in the United States than they are elsewhere, where there are stricter price controls.
Because drug companies typically hold exclusive patents for their drugs for a period of time, they tend not to have much competition. That gives them room to bargain up prices. And without a single-payer system on the other end bargaining down, costs tend to rise in the United States. "There’s a supplier and then a bunch of purchasers [insurance companies]," said Aaron Kesselheim, a professor of medicine at Harvard Medical School. "The supplier has full control."
You can see that with individual drugs. The cost of the cancer medicine Gleevec is higher here:
So is the cost of the multiple sclerosis treatment Copaxone:
The examples are endless.
4) The US system arguably has some upsides, too
The high prices in the United States are a huge, obvious drawback. But experts say there are some advantages to the US system. For one, drug companies are more likely to introduce drugs in the United States first, to get those higher prices. "New drugs come to the market here a little bit faster than in other countries," said Johns Hopkins professor Gerard Anderson. Other countries then tend to pivot off US prices, using them as the baseline.
The US system also arguably encourages innovation, says Amitabh Chandra, a health policy professor at the Harvard Kennedy School. "The innovation is coming from the patent system, and it's coming from the higher market size." Because there's no government regulator setting a ceiling for prices and squeezing out some drugs, the market is bigger. If that market shrank, we might not see as many new drugs coming out.
Margot Sanger-Katz of the New York Times recently reached a similar conclusion: Higher US prices can encourage innovation, which benefits people in many other countries. "Note that connection is true even if you think most innovations come from universities or the NIH rather than being hatched by Big Pharma," she added. "There is still a pot at the end of the rainbow for the significant innovators in this process."
So there are trade-offs to this US system — and there are, potentially, real trade-offs to changing it.
5) Drug spending is rising — and becoming a bigger political issue
The higher-cost aspect, however, is becoming more and more salient in recent years. In the United States, spending on drugs has more than doubled in the past 15 years, from $121.2 billion in 2000 up to nearly $374 billion in 2014. The average person spent $100 more on drugs in 2014 than in 2013.
There are a few reasons often cited for this increase. Part of this is due to the recent availability of new (and pricey) treatments, such as Sovaldi for hepatitis C, a number of immunotherapies for cancer, and treatments for multiple sclerosis, according to the IMS Institute for Healthcare Informatics. Meanwhile, there are fewer brand name drugs going generic. Last year, Americans spent $7.9 billion on Sovaldi, another $1.6 billion on cancer treatments, and nearly $2 billion to multiple sclerosis treatments. Spending on diabetes drugs totaled $32 billion.
But this isn't just a recent trend, either. Drug prices have been rising in America for decades, as my colleague Sarah Kliff writes. In response, insurers have been forced to either increase premiums or limit the drug coverage they offer. The Kaiser Family Foundation's annual survey of benefits last year found that the number of workers with a deductible over $2,000 has more than doubled since 2011.
The latter means that more Americans have to pay out of pocket for key drugs. And the Affordable Care Act is not expected to halt those trends.
6) Democrats want to solve the problem by importing more drugs from Canada
High drug costs are likely to be a health care election issue you'll hear a lot about next year. Republicans still seem to be groping for a way to respond. On the Democratic side, Bernie Sanders and Hillary Clinton, have put forward a few specific proposals aimed at addressing the problem.
One idea favored by Democrats is to allow Americans to import drugs from Canada — something that's already happening now through a gray market of online pharmacies. The experts I spoke to, however, explained that this would be more of a short-term fix: It might alleviate shortages in the United States and add some competition to the US marketplace, but it wouldn't change the fundamental dynamic described above.
Sanders and Clinton also want to allow Medicare to negotiate drug prices, since as the largest buyer the government program could presumably exert some sway, much as single-payer plans do in other countries. Clinton has also proposed creating monthly caps on out-of-pocket drug spending, while Sanders want to see drug companies be more transparent in what they spend on R&D.
Whatever happens on the campaign trail, however, the drug price issue isn't likely to go away. Pharmaceutical spending is rising, Americans are paying more out of pocket for these drugs, and we're seeing an increase in expensive new medicines coming online at a time when fewer brand-name drugs are going generic. The unique features of the US drug-pricing system are becoming impossible to ignore.